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KMID : 0043320100330030381
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Archives of Pharmacal Research
2010 Volume.33 No. 3 p.381 ~ p.385
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Naphthoquinones from Catalpa ovata and Their Inhibitory Effects on the Production of Nitric Oxide
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Hwang Bang-Yeon
Park Byeong-Min
Hong Seong-Su
Kang Shin-Jung
Shin Yoo-Su
Jung Jae-Kyung
Hong Jin-Tae
Kim Young-Soo
Lee Mi-Kyeong
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Abstract
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Bioassay-guided fractionation of a CH2Cl2-soluble fraction of the stems of Catalpa ovata led to isolation of a new naphthoquinone, 4-hydroxy-2-(2-methoxy-3-hydroxy-3-methyl-but-1-enyl)-4-hydro-1H-naphthalen-1-one (10), together with nine known compounds, catalponol (1), catalponone (2), catalpalactone (3), α-lapachone (4), 9-hydroxy-α-lapachone (5), 4,9-dihydroxy-α-lapachone (6), 9-methoxy-α-lapachone (7), 4-oxo-α-lapachone (8), and 9-methoxy-4-oxo-α-lapachone (9). The structures were elucidated on the basis of spectroscopic analyses. The inhibitory effects of these isolates on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells were evaluated. Among them, catapalactone (3), 9-hydroxy-α-lapachone (5) and 4,9-dihydroxy-α-lapachone (6) exhibited potent inhibitory effects, with IC50 values of 9.80, 4.64 and 2.73 μM, respectively.
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KEYWORD
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Catalpa ovata, Bignoniaceae, Naphthoquinone, Nitric oxide inhibitor
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